Sunderland and Middlesbrough had been drawn together four times in the FA Cup before this season. Sunderland have progressed twice, Middlesbrough once on the result and once because the Wearsiders were disqualified.
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Middlesbrough have won none of the last five matches against Sunderland in all competitions (D3 L2), despite being ahead in four of the games.
The Black Cats haven't progressed beyond Round 4 since they made the 2004 FA Cup semi-finals.
Sunderland have won only five of their last 12 FA Cup games against sides from a lower division.
Boro have progressed to the next round on the last four occasions they have reached the fourth round.
Middlesbrough have won only two of their last 14 FA Cup games against Premier League opponents.