Sheffield Wednesday have lost none of the last six meetings with Blackpool in all competitions, winning three.
The Owls and the Tangerines have met twice in cup competition this season, drawing both games.
The Owls have already knocked the Tangerines out of the carling Cup this season with a 4-2 win on penalties in August.
The two sides have been drawn against each other twice; in 1947 when Wednesday progressed and in 1953 when Blackpool went through.
Blackpool haven't beaten a fellow league side in the FA Cup since December 2006.
Sheffield Wednesday have won seven of their last nine FA Cup matches.
Wednesday are unbeaten in their last five home matches against Blackpool.
Clinton Morrison has scored six goals in his last six FA Cup starts.